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... this effect was in addition to walnuts reducing levels of “bad” cholesterol (low-density lipoprotein cholesterol (ldl)) in the blood

... new research presented at the 238th national meeting of the american chemical society reveals that oxycholesterol, another form of cholesterol, may be the most serious cardiovascular health threat of all ... “total cholesterol, low-density lipoprotein cholesterol (ldl), and the heart-healthy high-density lipoprotein cholesterol (hdl) are still important health issues,” said study leader zhen-yu chen, phd, of chinese university of hong kong ... our work demonstrated that oxycholesterol boosts total cholesterol levels and promotes atherosclerosis [“hardening of the arteries”] more than non-oxidized cholesterol

... with all the focus on ldl (bad) cholesterol, a ‘virtually unknown’ form called oxycholesterol may pose the biggest heart health threat, say chinese scientists ... "total cholesterol, low-density lipoprotein cholesterol (ldl), and the heart-healthy high-density lipoprotein cholesterol (hdl) are still important health issues," said lead researcher zhen-yu chen, phd ... "our work demonstrated that oxycholesterol boosts total cholesterol levels and promotes atherosclerosis ["hardening of the arteries"] more than non-oxidized cholesterol ... " sources in an email communication with foodnavigator, dr chen said: “foods of animal origins contain cholesterol, which is stable at room temperature ... however, it is susceptible to oxidation to produce the cholesterol oxidation products during heating, particularly, long frying and high temperature ... “the amount of cholesterol consumed from diet is about 300-500 mg cholesterol per day per person while cholesterol oxidation products could reach up to 10 per cent total cholesterol in diet ... according to the hong kong-based researchers, theirs is one of the first studies on oxycholesterol's effects in raising blood cholesterol levels, compared to non-oxidized cholesterol ... study details according to findings presented at this week’s 238th national meeting of the american chemical society, hamsters fed a diet high in oxycholesterol displayed blood cholesterol increases of up to 22 per cent more than hamsters eating non-oxidized cholesterol ... the oxycholesterol-fed group also showed greater deposition of cholesterol in the lining of their arteries and a tendency to develop larger deposits of cholesterol, called atherosclerotic plaques ... “statin is a type of drug which decreases cholesterol synthesis and thus decreases the cholesterol in blood,” he said ... “oxidized cholesterol is mainly from diet and statin should not have effect on oxidized cholesterol in blood but it needs to be proved

... while most children developed high cholesterol after starting the diet, in half of them, cholesterol gradually improved returning to normal or near-normal levels, with or without modifications to their diet to reduce fat intake ... researchers point out that diet modifications—including reducing total fat content or certain types of fats called saturated fats and adding nutritional supplements—reduced high cholesterol just as much as doing nothing ... high cholesterol is defined as total cholesterol greater than 200 mg per deciliter of blood, bad or ldl (low-density lipoprotein) cholesterol greater than 130, triglycerides greater than 130, and good or hdl (high-density lipoprotein) lower than 35 ... “we are greatly encouraged by our findings because the nearly half of the children on the diet were either able to maintain healthy cholesterol or gradually metabolized the extra fat and returned to somewhat normal cholesterol levels,” says senior investigator eric kossoff, md, a pediatric neurologist at hopkins children’s

... " plant sterols and sterol esters are used have been shown to lower the level of harmful low-density lipoprotein cholesterol, thereby actively reducing the risk of heart disease

... writing in the journal science , researchers from ut southwestern medical center in dallas and baylor college of medicine in houston showed that the compound, guggulsterone, locks the fxr receptor which regulates cholesterol metabolism ... dr david mangelsdorf, professor of pharmacology and an investigator in the howard hughes medical institute (hhmi) at ut southwestern, and his colleagues had previously revealed fxr's role in the body's conversion of cholesterol to bile acids ... when the bile acids reach a certain level in the body, fxr is activated to interrupt the cholesterol-to-bile-acid process ... "if you disturb it, it changes how cholesterol is metabolised ... the mouse model tests confirmed the assay results and showed that cholesterol levels fell in fxr-positive mice that were given guggulsterone ... mangelsdorf said the work could lead to new drugs to control cholesterol by creating compounds based on the chemical structure of guggulsterone ... those drugs would prevent fxr from interrupting cholesterol metabolism in people whose bodies are not getting rid of enough cholesterol before the process shuts down ... an ethyl acetate extract of this resin has been found to lower low-density lipoprotein cholesterol and triglycerides in humans